Molecular Precision Mental Health

Molecular Precision Mental Health

Dr. Cristina Thieme, (née Topor) MD
Psychiatric Specialist

Research interests/ Focus of work:
Early phase clinical trials, Innovative treatments for psychiatric disorders


Academic Education:
2009–2015 Study of Medicine, Johannes-Gutenberg-University Mainz
2015 Medical license
Doctoral thesis:
2016 "Erkennung emotionaler Gesichtsausdrücke in einem EEG-Paradigma zur Erstellung einer gesunden Referenzgruppe.", Johannes-Gutenberg-University Mainz
Professional experience:
since 2016 Registrar in Psychiatry and Psychotherapy, Dept. of Psychiatry and Psychotherapy, Central Institute of Mental Health (Director: Prof. Dr. A. Meyer-Lindenberg)

  • Maurus, I., Hasan, A., Schmitt, A., Roeh, A., Keeser, D., Malchow, B., Schneider-Axmann, T., Hellmich, M., Schmied, S., Lembeck, M., Keller-Varady, K., Papazova, I., Hirjak, D., Topor, C. E., Walter, H., Mohnke, S., Vogel, B. O., Wolwer, W., Schneider, F., Henkel, K., Meyer-Lindenberg, A. and Falkai, P.: Aerobic endurance training to improve cognition and enhance recovery in schizophrenia: design and methodology of a multicenter randomized controlled trial. Eur Arch Psychiatry Clin Neurosci (2020).
  • Sambataro, F., Fritze, S., Rashidi, M., Topor, C. E., Kubera, K. M., Wolf, R. C. and Hirjak, D.: Moving forward: distinct sensorimotor abnormalities predict clinical outcome after 6 months in patients with schizophrenia. Eur Neuropsychopharmacol 36, 72 (2020).
  • Fritze, S., Sambataro, F., Kubera, K. M., Bertolino, A. L., Topor, C. E., Wolf, R. C. and Hirjak, D.: Neurological soft signs in schizophrenia spectrum disorders are not confounded by current antipsychotic dosage. Eur Neuropsychopharmacol 31, 47 (2020).
  • Fritze, S., Bertolino, A. L., Kubera, K. M., Topor, C. E., Schmitgen, M. M., Wolf, R. C. and Hirjak, D.: Differential contributions of brainstem structures to neurological soft signs in first- and multiple-episode schizophrenia spectrum disorders. Schizophr Res 210, 101 (2019).
  • Hefter, D., Topor, C. E., Gass, P. and Hirjak, D.: Two Sides of the Same Coin: A Case Report of First-Episode Catatonic Syndrome in a High-Functioning Autism Patient. Front Psychiatry 10, 224 (2019).
  • Hirjak, D., Kubera, K. M., Northoff, G., Fritze, S., Bertolino, A. L., Topor, C. E., Schmitgen, M. M. and Wolf, R. C.: Cortical Contributions to Distinct Symptom Dimensions of Catatonia. Schizophr Bull 45, 1184 (2019).
  • Leweke, F. M., Mueller, J. K., Lange, B., Fritze, S., Topor, C. E., Koethe, D. and Rohleder, C.: Role of the Endocannabinoid System in the Pathophysiology of Schizophrenia: Implications for Pharmacological Intervention. CNS Drugs 32, 605 (2018).
  • Rohleder, C., Koethe, D., Fritze, S., Topor, C. E., Leweke, F. M. and Hirjak, D.: Neural correlates of binocular depth inversion illusion in antipsychotic-naive first-episode schizophrenia patients. Eur Arch Psychiatry Clin Neurosci 269, 897 (2019).